Chemical Properties of Sulfamethazine (CAS 57-68-1)

InChI

InChI=1S/C12H14N4O2S/c1-8-7-9(2)15-12(14-8)16-19(17,18)11-5-3-10(13)4-6-11/h3-7H,13H2,1-2H3,(H,14,15,16)

InChI Key

ASWVTGNCAZCNNR-UHFFFAOYSA-N

Formula

C12H14N4O2S

SMILES

Cc1cc(C)nc(NS(=O)(=O)c2ccc(N)cc2)n1

Molecular Weight¹

278.33

CAS

57-68-1

Other Names

• (p-Aminobenzolsulfonyl)-2-amino-4,6-dimethylpyrimidin
• 2-(4-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
• 2-(4-Aminobenzenesulfonylamino)-4,6-dimethylpyrimidine
• 2-(4-Aminobenzenesulfonylamino)-4,6-dimethylpyrimidine (sulfamethazine)
• 2-(p-Aminobenzenesulfonamido)-4,6-dimethylpyrimidine
• 2-Sulfanilamido-4,6-dimethylpyrimidine
• 4,6-Dimethyl-2-sulfanilamidopyrimidine
• 4-Amino-N-(2,6-dimethyl-4-pyrimidinyl)benzenesulfonamide
• 4-Amino-N-(4,6-dimethyl-2-pyrimidinyl)benzenesulfonamide
• 6-(4'-Aminobenzol-sulfonamido)-2,4-dimethylpyrimidin
• A-502
• Azolmetazin
• Benzenesulfonamide, 4-amino-N-(2,6-dimethyl-4-pyrimidinyl)-
• Calfspan
• Calfspan tablets
• Cremomethazine
• Diazil
• Diazilsulfadine
• Diazyl
• Dimezathine
• Dimidim-R
• Dimidin-R
• Hava-Span
• Intradine
• Kelametazine
• Mermeth
• Metazin
• N(Sup1)-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
• N(Sup1)-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
• N(sup1)-(2,6-Dimethylpyrimid-4-yl)sulfanilamide
• N-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
• N1-(4,6-Dimethyl-2-pyrimidinyl)sulfanilamide
• N1-(4,6-Dimethyl-2-pyrimidyl)sulfanilamide
• NCI-C56600
• Neasina
• Neazina
• Panazin
• Pirmazin
• Primazin
• S-Dimidine
• SA III
• Spanbolet
• Sulfa-Isodimerazine
• SulfaSURE SR Bolus
• Sulfadimerazine
• Sulfadimesin
• Sulfadimesine
• Sulfadimethyldiazine
• Sulfadimethylpyrimidine
• Sulfadimezin
• Sulfadimezine
• Sulfadimidin
• Sulfadimidine
• Sulfadine
• Sulfaisodimidine
• Sulfametazyny
• Sulfamethiazine
• Sulfamethin
• Sulfamezathine
• Sulfamidine
• Sulfanilamide, N(sup1)-(4,6-dimethyl-2-pyrimidinyl)-
• Sulfanilamide, N1-(4,6-dimethyl-2-pyrimidinyl)-
• Sulfisomidin
• Sulfodimesin
• Sulfodimezine
• Sulka K Boluses
• Sulmet
• Sulphadimethylpyrimidine
• Sulphadimidine
• Sulphamethasine
• Sulphamethazine
• Sulphamezathine
• Sulphamidine
• Sulphodimezine
• Superseptil
• Superseptyl
• Vertolan
• benzenesulfonamide, 4-amino-N-(4,6-dimethyl-2-pyrimidinyl)-

• Δ_fusH : Enthalpy of fusion at a given temperature (kJ/mol).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• I_np : Non-polar retention indices.
• T_fus : Normal melting (fusion) point (K).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Property	Value	Unit	Source
log10WS	-2.51		Aq. Sol...
logPoct/wat	1.476		Crippen Calculated Property
McVol	200.430	ml/mol	McGowan Calculated Property
Inp	2613.00		NIST
Tfus	[467.65; 471.70]	K
Tfus	467.65	K	Aq. Sol...
Tfus	469.20	K	Solutio...
Tfus	468.60 ± 2.00	K	NIST
Tfus	471.70 ± 0.50	K	NIST

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
ΔfusH	[31.10; 39.20]	kJ/mol	[469.00; 471.60]
ΔfusH	39.20	kJ/mol	469.00	NIST
ΔfusH	31.10	kJ/mol	471.60	NIST

Similar Compounds

Find more compounds similar to Sulfamethazine.

Mixtures

• Sulfamethazine + Methyl Alcohol + Water
• Sulfamethazine + Methyl Alcohol
• Sulfamethazine + Water
• Ethanol + Sulfamethazine + Water
• Ethanol + Sulfamethazine
• Sulfamethazine + 1-Octanol

Sources

• Crippen Method
• Solubility and solution thermodynamics of sulfamerazine and sulfamethazine in some ethanol + water mixtures
• Solution thermodynamics and preferential solvation of sulfamethazine in (methanol + water) mixtures
• Solubilities of Sulfadiazine, Sulfamethazine, Sulfadimethoxine, Sulfamethoxydiazine, Sulfamonomethoxine, Sulfamethoxazole, and Sulfachloropyrazine in Water from (298.15 to 333.15) K
• Solubilities of Sulfamethazine, Sulfadimethoxine, Sulfamethoxydiazine, Sulfamonomethoxine, Sulfamethoxazole, and Sulfaquinoxaline in 1-Octanol from (298.15 to 333.15) K
• Aqueous Solubility Prediction Method
• McGowan Method
• NIST Webbook

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