Chemical Properties of Sulfadiazine (CAS 68-35-9)

InChI

InChI=1S/C10H10N4O2S/c11-8-2-4-9(5-3-8)17(15,16)14-10-12-6-1-7-13-10/h1-7H,11H2,(H,12,13,14)

InChI Key

SEEPANYCNGTZFQ-UHFFFAOYSA-N

Formula

C10H10N4O2S

SMILES

Nc1ccc(S(=O)(=O)Nc2ncccn2)cc1

Molecular Weight¹

250.28

CAS

68-35-9

Other Names

• 2-(4-Aminobenzenesulfonamido)pyrimidine
• 2-(4-Aminobenzenesulfonylamino)pyrimidine
• 2-(p-Aminobenzenesulfonamido)pyrimidin
• 2-Sulfanilamidopyrimidine
• 2-Sulfanilylaminopyrimidine
• 2-Sulfapyrimidine
• 4-Amino-N-(2-pyrmidinyl)benzene sulfonamide (sulfadiazine)
• 4-[[(Pyrimidin-2-yl)amino]sulfonyl]aniline
• 4-amino-N-2-pyrimidinylbenzenesulfonamide
• A-306
• Adiazin
• Adiazine
• Benzenesulfonamide, 4-amino-N-2-pyrimidinyl-
• Coco-Diazine
• Codiazine
• Cremodiazine
• Cremotres
• Debenal
• Deltazina
• Di-Azo-Mul
• Diazin
• Diazolone
• Diazovit
• Diazyl
• Eskadiazine
• Honey diazine
• Lipo-Diazine
• Lipo-Levazine
• Liquadiazine
• Metha-Meridiazine
• Microsulfon
• N(Sup1)-2-Pyrimidinylsulfanilamide
• N(Sup1)-2-Pyrimidylsulfanilamide
• N1-2-Pyrimidinylsulfanilamide
• N1-2-Pyrimidylsulfanilamide
• Neazine
• Neotrizine
• Palatrize
• Pecta-diazine, suspension
• Piridisir
• Pirimal
• Pyrimal
• Pyrimidine, 2-sulfanilamido-
• Quadetts
• Quadramoid
• RP 2616
• S. N. 112
• SDA
• Sanodiazine
• Silvadene
• Spofadrizine
• Sterazine
• Sulfadiazene
• Sulfadiazin
• Sulfadiazina Reig Jofre
• Sulfanilamide, N1-2(1H)-pyrimidinylidene-
• Sulfanilamide, N1-2-pyrimidinyl-
• Sulfanilamidopyrimidine
• Sulfapirimidin
• Sulfapyrimidin
• Sulfapyrimidine
• Sulfatryl
• Sulfazin
• Sulfazine
• Sulfolex
• Sulfonsol
• Sulfose
• Sulphadiazine
• Sulphadiazine E
• Terfonyl
• Theradiazine
• Thi-Di-Mer
• Tri-Sulfameth
• Trifonamide
• Triple Sulfas
• Trisem
• Truozine

• Δ_fusH : Enthalpy of fusion at a given temperature (kJ/mol).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• I_np : Non-polar retention indices.
• T_fus : Normal melting (fusion) point (K).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Property	Value	Unit	Source
log10WS	-1.54		Aq. Sol...
logPoct/wat	0.860		Crippen Calculated Property
McVol	172.250	ml/mol	McGowan Calculated Property
Inp	2523.00		NIST
Tfus	[527.27; 538.80]	K
Tfus	527.27	K	Aq. Sol...
Tfus	538.80 ± 0.50	K	NIST
Tfus	534.00 ± 3.00	K	NIST
Tfus	531.00 ± 4.00	K	NIST

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
ΔfusH	[31.20; 44.30]	kJ/mol	[520.40; 538.70]
ΔfusH	44.30	kJ/mol	520.40	NIST
ΔfusH	44.30	kJ/mol	532.70	NIST
ΔfusH	31.20	kJ/mol	538.70	NIST
ΔfusH	31.20	kJ/mol	538.70	NIST

Similar Compounds

Find more compounds similar to Sulfadiazine.

Mixtures

• Sulfadiazine + Methyl Alcohol + Water
• Sulfadiazine + 1,4-Dioxane + Water
• Sulfadiazine + Water
• Sulfadiazine + Ethanol
• 1-Propanol + Sulfadiazine
• Sulfadiazine + Acetone
• Trichloromethane + Sulfadiazine
• Sulfadiazine + Methyl Alcohol
• Sulfadiazine + Isopropyl Alcohol

Sources

• Crippen Method
• Solubility and preferential solvation of sulfadiazine inmethanol + water mixtures at several temperatures
• Solubility temperature dependence and preferential solvation of sulfadiazine in 1,4-dioxane + water co-solvent mixtures
• Solubilities of Sulfadiazine, Sulfamethazine, Sulfadimethoxine, Sulfamethoxydiazine, Sulfamonomethoxine, Sulfamethoxazole, and Sulfachloropyrazine in Water from (298.15 to 333.15) K
• Solubilities of Sulfadiazine in Methanol, Ethanol, 1-Propanol, 2-Propanol, Acetone, and Chloroform from (294.15 to 318.15) K
• Aqueous Solubility Prediction Method
• McGowan Method
• NIST Webbook

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