Mixture of Indomethacin + Ethanol + Ethyl Acetate

Datasets

1. Mole fraction (4)
2. ρ_l - Mass density, kg/m3 (4)

Mole fraction of Indomethacin (1) [ref]

Operational condition: Pressure, kPa = 101 (Crystal)

Fixed		Measured
Solvent: Mass fraction of Ethanol (2) - Crystal	Temperature, K - Crystal	Mole fraction of Indomethacin (1) - Liquid
0.0000	293.15	0.0105
0.0000	298.15	0.0120
0.0000	303.15	0.0138
0.0000	308.15	0.0157
0.0000	313.15	0.0180
0.1000	293.15	0.0226
0.1000	298.15	0.0248
0.1000	303.15	0.0272
0.1000	308.15	0.0297
0.1000	313.15	0.0325
0.2000	293.15	0.0294
0.2000	298.15	0.0315
0.2000	303.15	0.0345
0.2000	308.15	0.0374
0.2000	313.15	0.0399
0.3000	293.15	0.0309
0.3000	298.15	0.0336
0.3000	303.15	0.0362
0.3000	308.15	0.0391
0.3000	313.15	0.0412
0.4000	293.15	0.0287
0.4000	298.15	0.0314
0.4000	303.15	0.0340
0.4000	308.15	0.0370
0.4000	313.15	0.0391
0.5000	293.15	0.0239
0.5000	298.15	0.0262
0.5000	303.15	0.0285
0.5000	308.15	0.0319
0.5000	313.15	0.0345
0.6000	293.15	0.0184
0.6000	298.15	0.0205
0.6000	303.15	0.0230
0.6000	308.15	0.0260
0.6000	313.15	0.0286
0.7000	293.15	0.0131
0.7000	298.15	0.0151
0.7000	303.15	0.0169
0.7000	308.15	0.0198
0.7000	313.15	0.0222
0.8000	293.15	0.0088
0.8000	298.15	0.0100
0.8000	303.15	0.0118
0.8000	308.15	0.0143
0.8000	313.15	0.0164
0.9000	293.15	0.0056
0.9000	298.15	0.0066
0.9000	303.15	0.0078
0.9000	308.15	0.0097
0.9000	313.15	0.0113
1.0000	293.15	0.0033
1.0000	298.15	0.0042
1.0000	303.15	0.0049
1.0000	308.15	0.0062
1.0000	313.15	0.0074

Mole fraction of Indomethacin (1) [ref]

Operational conditions:

• Pressure, kPa = 100 (Liquid)
• Temperature, K = 298.15 (Liquid)

Solvent: Mole fraction of Ethanol (2) - Liquid	Mole fraction of Indomethacin (1) - Liquid
0.0000	0.0111
0.0910	0.0197
0.1750	0.0248
0.2890	0.0272
0.3890	0.0300
0.5070	0.0266
0.6100	0.0252
0.7000	0.0206
0.8170	0.0134
0.9160	0.0073
1.0000	0.0044

Mole fraction of Indomethacin (1) [ref]

Operational condition: Pressure, kPa = 101 (Crystal)

Fixed		Measured
Solvent: Mass fraction of Ethanol (2) - Crystal	Temperature, K - Crystal	Mole fraction of Indomethacin (1) - Liquid
0.0000	293.15	0.0105
0.0000	298.15	0.0120
0.0000	303.15	0.0138
0.0000	308.15	0.0157
0.0000	313.15	0.0180
0.1000	293.15	0.0226
0.1000	298.15	0.0248
0.1000	303.15	0.0272
0.1000	308.15	0.0297
0.1000	313.15	0.0325
0.2000	293.15	0.0294
0.2000	298.15	0.0315
0.2000	303.15	0.0345
0.2000	308.15	0.0374
0.2000	313.15	0.0399
0.3000	293.15	0.0309
0.3000	298.15	0.0336
0.3000	303.15	0.0362
0.3000	308.15	0.0391
0.3000	313.15	0.0412
0.4000	293.15	0.0287
0.4000	298.15	0.0314
0.4000	303.15	0.0340
0.4000	308.15	0.0370
0.4000	313.15	0.0391
0.5000	293.15	0.0239
0.5000	298.15	0.0262
0.5000	303.15	0.0285
0.5000	308.15	0.0319
0.5000	313.15	0.0345
0.6000	293.15	0.0184
0.6000	298.15	0.0205
0.6000	303.15	0.0230
0.6000	308.15	0.0260
0.6000	313.15	0.0286
0.7000	293.15	0.0131
0.7000	298.15	0.0151
0.7000	303.15	0.0169
0.7000	308.15	0.0198
0.7000	313.15	0.0222
0.8000	293.15	0.0088
0.8000	298.15	0.0100
0.8000	303.15	0.0118
0.8000	308.15	0.0143
0.8000	313.15	0.0164
0.9000	293.15	0.0056
0.9000	298.15	0.0066
0.9000	303.15	0.0078
0.9000	308.15	0.0097
0.9000	313.15	0.0113
1.0000	293.15	0.0033
1.0000	298.15	0.0042
1.0000	303.15	0.0049
1.0000	308.15	0.0062
1.0000	313.15	0.0074

Mole fraction of Indomethacin (1) [ref]

Operational conditions:

• Pressure, kPa = 100 (Liquid)
• Temperature, K = 298.15 (Liquid)

Solvent: Mole fraction of Ethanol (2) - Liquid	Mole fraction of Indomethacin (1) - Liquid
0.0000	0.0111
0.0910	0.0197
0.1750	0.0248
0.2890	0.0272
0.3890	0.0300
0.5070	0.0266
0.6100	0.0252
0.7000	0.0206
0.8170	0.0134
0.9160	0.0073
1.0000	0.0044

Mass density, kg/m3 [ref]

Operational condition: Pressure, kPa = 101 (Liquid)

Fixed			Measured
Temperature, K - Liquid	Solvent: Mass fraction of Ethanol (2) - Liquid	Mole fraction of Indomethacin (1) - Liquid	Mass density, kg/m3 - Liquid
293.15	0.0000	0.0105	914.0
293.15	0.1000	0.0226	918.0
293.15	0.2000	0.0294	918.7
293.15	0.3000	0.0309	913.5
293.15	0.4000	0.0287	902.3
293.15	0.5000	0.0239	886.5
293.15	0.6000	0.0184	869.7
293.15	0.7000	0.0131	849.2
293.15	0.8000	0.0088	830.8
293.15	0.9000	0.0056	813.7
293.15	1.0000	0.0033	798.8
298.15	0.0000	0.0120	910.1
298.15	0.1000	0.0248	915.0
298.15	0.2000	0.0315	915.2
298.15	0.3000	0.0336	910.0
298.15	0.4000	0.0314	899.5
298.15	0.5000	0.0262	884.4
298.15	0.6000	0.0205	866.0
298.15	0.7000	0.0151	846.5
298.15	0.8000	0.0100	828.3
298.15	0.9000	0.0066	811.2
298.15	1.0000	0.0042	796.6
303.15	0.0000	0.0138	906.4
303.15	0.1000	0.0272	912.0
303.15	0.2000	0.0345	912.9
303.15	0.3000	0.0362	908.5
303.15	0.4000	0.0340	898.6
303.15	0.5000	0.0285	882.2
303.15	0.6000	0.0230	865.3
303.15	0.7000	0.0169	845.3
303.15	0.8000	0.0118	827.0
303.15	0.9000	0.0078	809.5
303.15	1.0000	0.0049	794.3
308.15	0.0000	0.0157	902.7
308.15	0.1000	0.0297	910.4
308.15	0.2000	0.0374	912.5
308.15	0.3000	0.0391	907.7
308.15	0.4000	0.0370	897.5
308.15	0.5000	0.0319	883.0
308.15	0.6000	0.0260	866.1
308.15	0.7000	0.0198	846.8
308.15	0.8000	0.0143	828.0
308.15	0.9000	0.0097	809.6
308.15	1.0000	0.0062	793.2
313.15	0.0000	0.0180	899.6
313.15	0.1000	0.0325	908.3
313.15	0.2000	0.0399	910.0
313.15	0.3000	0.0412	905.2
313.15	0.4000	0.0391	895.7
313.15	0.5000	0.0345	881.9
313.15	0.6000	0.0286	865.4
313.15	0.7000	0.0222	846.8
313.15	0.8000	0.0164	827.8
313.15	0.9000	0.0113	809.0
313.15	1.0000	0.0074	792.1

Mass density, kg/m3 [ref]

Operational conditions:

• Temperature, K = 298.15 (Liquid)
• Pressure, kPa = 100 (Liquid)

Solvent: Mole fraction of Ethanol (2) - Liquid	Mass density, kg/m3 - Liquid
0.0000	900.0
0.0910	900.0
0.1750	897.0
0.2890	896.0
0.3890	893.0
0.5070	883.0
0.6100	875.0
0.7000	859.0
0.8170	832.0
0.9160	804.0
1.0000	786.0

Mass density, kg/m3 [ref]

Operational condition: Pressure, kPa = 101 (Liquid)

Fixed			Measured
Temperature, K - Liquid	Solvent: Mass fraction of Ethanol (2) - Liquid	Mole fraction of Indomethacin (1) - Liquid	Mass density, kg/m3 - Liquid
293.15	0.0000	0.0105	914.0
293.15	0.1000	0.0226	918.0
293.15	0.2000	0.0294	918.7
293.15	0.3000	0.0309	913.5
293.15	0.4000	0.0287	902.3
293.15	0.5000	0.0239	886.5
293.15	0.6000	0.0184	869.7
293.15	0.7000	0.0131	849.2
293.15	0.8000	0.0088	830.8
293.15	0.9000	0.0056	813.7
293.15	1.0000	0.0033	798.8
298.15	0.0000	0.0120	910.1
298.15	0.1000	0.0248	915.0
298.15	0.2000	0.0315	915.2
298.15	0.3000	0.0336	910.0
298.15	0.4000	0.0314	899.5
298.15	0.5000	0.0262	884.4
298.15	0.6000	0.0205	866.0
298.15	0.7000	0.0151	846.5
298.15	0.8000	0.0100	828.3
298.15	0.9000	0.0066	811.2
298.15	1.0000	0.0042	796.6
303.15	0.0000	0.0138	906.4
303.15	0.1000	0.0272	912.0
303.15	0.2000	0.0345	912.9
303.15	0.3000	0.0362	908.5
303.15	0.4000	0.0340	898.6
303.15	0.5000	0.0285	882.2
303.15	0.6000	0.0230	865.3
303.15	0.7000	0.0169	845.3
303.15	0.8000	0.0118	827.0
303.15	0.9000	0.0078	809.5
303.15	1.0000	0.0049	794.3
308.15	0.0000	0.0157	902.7
308.15	0.1000	0.0297	910.4
308.15	0.2000	0.0374	912.5
308.15	0.3000	0.0391	907.7
308.15	0.4000	0.0370	897.5
308.15	0.5000	0.0319	883.0
308.15	0.6000	0.0260	866.1
308.15	0.7000	0.0198	846.8
308.15	0.8000	0.0143	828.0
308.15	0.9000	0.0097	809.6
308.15	1.0000	0.0062	793.2
313.15	0.0000	0.0180	899.6
313.15	0.1000	0.0325	908.3
313.15	0.2000	0.0399	910.0
313.15	0.3000	0.0412	905.2
313.15	0.4000	0.0391	895.7
313.15	0.5000	0.0345	881.9
313.15	0.6000	0.0286	865.4
313.15	0.7000	0.0222	846.8
313.15	0.8000	0.0164	827.8
313.15	0.9000	0.0113	809.0
313.15	1.0000	0.0074	792.1

Mass density, kg/m3 [ref]

Operational conditions:

• Temperature, K = 298.15 (Liquid)
• Pressure, kPa = 100 (Liquid)

Solvent: Mole fraction of Ethanol (2) - Liquid	Mass density, kg/m3 - Liquid
0.0000	900.0
0.0910	900.0
0.1750	897.0
0.2890	896.0
0.3890	893.0
0.5070	883.0
0.6100	875.0
0.7000	859.0
0.8170	832.0
0.9160	804.0
1.0000	786.0

Sources

• Thermodynamic analysis and enthalpy-entropy compensation for the solubility of indomethacin in aqueous and non-aqueous mixtures
• Solubilities of Organic Semiconductors and Nonsteroidal Anti-inflammatory Drugs in Pure and Mixed Organic Solvents: Measurement and Modeling with Hansen Solubility Parameter