Chemical Properties of Mefenamic Acid (CAS 61-68-7)

InChI

InChI=1S/C15H15NO2/c1-10-6-5-9-13(11(10)2)16-14-8-4-3-7-12(14)15(17)18/h3-9,16H,1-2H3,(H,17,18)

InChI Key

HYYBABOKPJLUIN-UHFFFAOYSA-N

Formula

C15H15NO2

SMILES

Cc1cccc(Nc2ccccc2C(=O)O)c1C

Molecular Weight¹

241.29

CAS

61-68-7

Other Names

• 2-((2,3-Dimethylphenyl)amino)benzoic acid
• 2-Diphenylaminecarboxylic acid, 2',3'-dimethyl-
• 2-[(2,3-Dimethylphenyl)amino]benzoic acid (mefenamic acid)
• AGN-1255
• Acide mefenamique
• Anthranilic acid, N-2,3-xylyl-
• Bafameritin-M
• Bafhameritin-M
• Benzoic acid, 2-[(2,3-dimethylphenyl)amino]-
• Bonabol
• CL 473
• CN-35355
• Coslan
• HL 1
• INF 3355
• In-M
• Lysalgo
• Mefacit
• Mefanamic acid
• Mefenacid
• Mefenaminsaeure
• Mephenamic acid
• Mephenaminic acid
• Methenamic acid
• N-(2,3-Dimethylphenyl)anthranilic acid
• N-(2,3-Xylyl)-2-aminobenzoic acid
• N-(2,3-Xylyl)anthranilic acid
• NSC 94437
• Namphen
• Parkemed
• Ponalar
• Ponstan
• Ponstan forte
• Ponstel
• Ponstil
• Ponstyl
• Pontal
• Tamany Bonsan
• Tanston
• Vialidon

• C_p,gas : Ideal gas heat capacity (J/mol×K).
• Δ_fG° : Standard Gibbs free energy of formation (kJ/mol).
• Δ_fH°_gas : Enthalpy of formation at standard conditions (kJ/mol).
• Δ_fusH° : Enthalpy of fusion at standard conditions (kJ/mol).
• Δ_fusH : Enthalpy of fusion at a given temperature (kJ/mol).
• Δ_subH° : Enthalpy of sublimation at standard conditions (kJ/mol).
• Δ_subH : Enthalpy of sublimation at a given temperature (kJ/mol).
• Δ_vapH° : Enthalpy of vaporization at standard conditions (kJ/mol).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• P_c : Critical Pressure (kPa).
• I_np : Non-polar retention indices.
• T_boil : Normal Boiling Point Temperature (K).
• T_c : Critical Temperature (K).
• T_fus : Normal melting (fusion) point (K).
• V_c : Critical Volume (m³/kmol).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Property	Value	Unit	Source
ΔfG°	95.00	kJ/mol	Joback Calculated Property
ΔfH°gas	-125.62	kJ/mol	Joback Calculated Property
ΔfusH°	32.31	kJ/mol	Joback Calculated Property
ΔsubH°	136.30 ± 0.80	kJ/mol	NIST
ΔvapH°	85.38	kJ/mol	Joback Calculated Property
log10WS	-3.38		Aq. Sol...
logPoct/wat	3.745		Crippen Calculated Property
McVol	192.110	ml/mol	McGowan Calculated Property
Pc	2850.52	kPa	Joback Calculated Property
Inp	[2201.00; 2201.00]
Inp	2201.00		NIST
Inp	2201.00		NIST
Tboil	807.12	K	Joback Calculated Property
Tc	1030.77	K	Joback Calculated Property
Tfus	[503.10; 503.65]	K
Tfus	503.65	K	Aq. Sol...
Tfus	503.10	K	Solubil...
Vc	0.720	m3/kmol	Joback Calculated Property

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
Cp,gas	[540.37; 597.89]	J/mol×K	[807.12; 1030.77]
Cp,gas	540.37	J/mol×K	807.12	Joback Calculated Property
Cp,gas	552.03	J/mol×K	844.40	Joback Calculated Property
Cp,gas	562.80	J/mol×K	881.67	Joback Calculated Property
Cp,gas	572.72	J/mol×K	918.95	Joback Calculated Property
Cp,gas	581.84	J/mol×K	956.22	Joback Calculated Property
Cp,gas	590.21	J/mol×K	993.50	Joback Calculated Property
Cp,gas	597.89	J/mol×K	1030.77	Joback Calculated Property
ΔfusH	[38.20; 38.70]	kJ/mol	[503.50; 503.60]
ΔfusH	38.70	kJ/mol	503.50	NIST
ΔfusH	38.25	kJ/mol	503.60	NIST
ΔfusH	38.20	kJ/mol	503.60	NIST
ΔsubH	132.70 ± 0.80	kJ/mol	377.50	NIST

Similar Compounds

Find more compounds similar to Mefenamic Acid.

Mixtures

• Ethanol + Mefenamic Acid
• 1-Octanol + Mefenamic Acid
• Carbon dioxide + Mefenamic Acid
• Water + Mefenamic Acid
• Formamide, N,N-dimethyl- + Mefenamic Acid
• Acetone + Mefenamic Acid
• Isopropyl Alcohol + Mefenamic Acid
• N,N-Dimethylacetamide + Mefenamic Acid
• Ethyl Acetate + Mefenamic Acid
• n-Hexane + Mefenamic Acid
• Heptane + Mefenamic Acid
• Cyclohexane + Mefenamic Acid

Sources

• Crippen Method
• Measurement and modeling of mefenamic acid solubility in supercritical carbon dioxide
• Solubility and pKa of select pharmaceuticals in water, ethanol, and 1-octanol
• Thermodynamic Study of Solubility for Imatinib Mesylate in Nine Monosolvents and Two Binary Solvent Mixtures from 278.15 to 318.15 K
• Solubility and Dissolution Thermodynamic Data of Mefenamic Acid Crystals in Different Classes of Organic Solvents
• Joback Method
• Aqueous Solubility Prediction Method
• McGowan Method
• NIST Webbook

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