- InChI
- InChI=1S/C15H10Cl2N2O2/c16-8-5-6-12-10(7-8)13(19-15(21)14(20)18-12)9-3-1-2-4-11(9)17/h1-7,15,21H,(H,18,20)
- InChI Key
- DIWRORZWFLOCLC-UHFFFAOYSA-N
- Formula
- C15H11Cl2N2O2
- SMILES
-
OC1=Nc2ccc(Cl)cc2C(c2ccccc2Cl)
=NC1O - Molecular Weight1
- 322.17
- CAS
- 846-49-1
- Other Names
-
- (.+/-.)-Lorazepam
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-
- 2H-1,4-Benzodiazepin-2-one, 7-chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-
- 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
- 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one ((±)lorazepam)
- 7-Chloro-5-(2-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one ((±)lorazepam)
- 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1H-1,4-benzodiazepin-2(3H)-one
- 7-Chloro-5-(o-chlorophenyl)-1,3-dihydro-3-hydroxy-2H-1,4-benzodiazepin-2-one
- Almazine
- Anxiedin
- Anxira
- Anzepam
- Aplacasse
- Apo-Lorazepam
- Aripax
- Ativan
- Azurogen
- Bonatranquan
- Bonton
- Delormetazepam
- Demethyllormetazepam
- Duralozam
- Efasedan
- Emotival
- Equitam
- Kalmalin
- Larpose
- Laubeel
- Lorabenz
- Loram
- Lorapam
- Lorat
- Lorax
- Lorazene
- Lorazep
- Lorazin
- Lorenin
- Loridem
- Lorsedal
- Lorsilan
- Lozepam
- Merlit
- NSC 289758
- Nervistop L
- Norlormetazepam
- Novhepar
- Orfidal
- Pro dorm
- Psicopax
- Punktyl
- Quait
- Renaquil
- Rocosgen
- Securit
- Sedatival
- Sedazin
- Sedizepan
- Sidenar
- Silence
- Somagerol
- Stapam
- Tavor
- Temesta
- Titus
- Tranqipam
- Trapax
- Upan
- Wy 4036
- Wypax
- o-Chlorooxazepam
- o-Chloroxazepam
- Cp,gas : Ideal gas heat capacity (J/mol×K).
- ΔfG° : Standard Gibbs free energy of formation (kJ/mol).
- ΔfH°gas : Enthalpy of formation at standard conditions (kJ/mol).
- ΔfusH° : Enthalpy of fusion at standard conditions (kJ/mol).
- ΔfusH : Enthalpy of fusion at a given temperature (kJ/mol).
- ΔvapH° : Enthalpy of vaporization at standard conditions (kJ/mol).
- log10WS : Log10 of Water solubility in mol/l.
- logPoct/wat : Octanol/Water partition coefficient.
- McVol : McGowan's characteristic volume (ml/mol).
- Pc : Critical Pressure (kPa).
- Inp : Non-polar retention indices.
- Tboil : Normal Boiling Point Temperature (K).
- Tc : Critical Temperature (K).
- Tfus : Normal melting (fusion) point (K).
- Vc : Critical Volume (m3/kmol).
- 1: Molecular weight from the IUPAC atomic weights tables.
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Physical Properties
| Property | Value | Unit | Source |
|---|---|---|---|
| ΔfG° | 284.62 | kJ/mol | Joback Calculated Property |
| ΔfH°gas | 44.82 | kJ/mol | Joback Calculated Property |
| ΔfusH° | 43.97 | kJ/mol | Joback Calculated Property |
| ΔvapH° | 112.23 | kJ/mol | Joback Calculated Property |
| log10WS | [-3.60; -1.77] |
|
|
| log10WS | -1.77 | Aq. Sol... | |
| log10WS | -3.60 | Estimat... | |
| logPoct/wat | 3.751 | Crippen Calculated Property | |
| McVol | 211.410 | ml/mol | McGowan Calculated Property |
| Pc | 3431.89 | kPa | Joback Calculated Property |
| Inp | [2375.00; 2492.80] |
|
|
| Inp | 2402.00 | NIST | |
| Inp | 2395.00 | NIST | |
| Inp | Outlier 2492.80 | NIST | |
| Inp | 2430.00 | NIST | |
| Inp | 2423.00 | NIST | |
| Inp | 2442.00 | NIST | |
| Inp | 2391.00 | NIST | |
| Inp | 2411.00 | NIST | |
| Inp | 2423.00 | NIST | |
| Inp | 2448.00 | NIST | |
| Inp | 2423.00 | NIST | |
| Inp | 2384.00 | NIST | |
| Inp | 2430.00 | NIST | |
| Inp | 2442.00 | NIST | |
| Inp | 2440.00 | NIST | |
| Inp | 2411.00 | NIST | |
| Inp | 2399.00 | NIST | |
| Inp | 2430.00 | NIST | |
| Inp | Outlier 2492.80 | NIST | |
| Inp | 2426.00 | NIST | |
| Inp | 2375.00 | NIST | |
| Inp | 2375.00 | NIST | |
| Inp | 2380.00 | NIST | |
| Inp | 2402.00 | NIST | |
| Inp | 2448.00 | NIST | |
| Inp | 2448.00 | NIST | |
| Inp | 2430.00 | NIST | |
| Inp | 2395.00 | NIST | |
| Inp | 2391.00 | NIST | |
| Inp | 2402.00 | NIST | |
| Tboil | 1001.08 | K | Joback Calculated Property |
| Tc | 1250.13 | K | Joback Calculated Property |
| Tfus | 439.75 | K | Aq. Sol... |
| Vc | 0.806 | m3/kmol | Joback Calculated Property |
Temperature Dependent Properties
| Property | Value | Unit | Temperature (K) | Source |
|---|---|---|---|---|
| Cp,gas | [624.98; 643.08] | J/mol×K | [1001.08; 1250.13] |
|
| Cp,gas | 624.98 | J/mol×K | 1001.08 | Joback Calculated Property |
| Cp,gas | 631.26 | J/mol×K | 1042.59 | Joback Calculated Property |
| Cp,gas | 636.19 | J/mol×K | 1084.10 | Joback Calculated Property |
| Cp,gas | 639.78 | J/mol×K | 1125.61 | Joback Calculated Property |
| Cp,gas | 642.07 | J/mol×K | 1167.12 | Joback Calculated Property |
| Cp,gas | 643.08 | J/mol×K | 1208.62 | Joback Calculated Property |
| Cp,gas | 642.83 | J/mol×K | 1250.13 | Joback Calculated Property |
| ΔfusH | [75.20; 92.57] | kJ/mol | [446.50; 453.20] |
|
| ΔfusH | 92.57 | kJ/mol | 446.50 | NIST |
| ΔfusH | 75.20 | kJ/mol | 453.20 | NIST |
Similar Compounds
Find more compounds similar to Lorazepam.
Mixtures
- Water + Lorazepam
- Ethanol + Lorazepam
- Ethanol + Water + Lorazepam
- Propylene Glycol + Water + Lorazepam
Sources
- Crippen Method
- Solubility of Chlordiazepoxide, Diazepam, and Lorazepam in Ethanol + Water Mixtures at 303.2 K
- Solubility of 7-Chloro-2-methylamino-5-phenyl-3H-1,4-benzodiazepine-4-oxide, 7-Chloro-1,3-dihydro-1-methyl-5-phenyl-2H-1,4-benzodiazepin-2-one, and 7-Chloro-5-(2-chlorophenyl)-3-hydroxy-1,3-dihydro-1,4-benzodiazepin-2-one in (Propane-1,2-diol + Water) at a Temperature of 303.2 K
- Joback Method
- Aqueous Solubility Prediction Method
- Estimated Solubility Method
- McGowan Method
- NIST Webbook
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Take the time to validate and double check the source of the data.
Outlier This icon means
that the value is more than 2 standard deviations away from the
property mean.