Chemical Properties of Megestrol acetate (CAS 595-33-5)

InChI

InChI=1S/C24H32O4/c1-14-12-18-19(22(4)9-6-17(27)13-21(14)22)7-10-23(5)20(18)8-11-24(23,15(2)25)28-16(3)26/h12-13,18-20H,6-11H2,1-5H3

InChI Key

RQZAXGRLVPAYTJ-UHFFFAOYSA-N

Formula

C24H32O4

SMILES

CC(=O)OC1(C(C)=O)CCC2C3C=C(C)C4=CC(=O)CCC4(C)C3CCC21C

Molecular Weight¹

384.51

CAS

595-33-5

Other Names

• 17-(acetyloxy)-6-methylpregna-4,6-diene-3,20-dione
• 17-Acetoxy-6-methylpregna-4,6-diene-3,20-dione
• 17-Hydroxy-6-methylpregna-4,6-diene-3,20-dione acetate
• 17-hydroxy-6-methylpregna-4,6-diene-3,20-dione 17-acetate
• 17«alpha»-Acetoxy-6-dehydro-6-methylprogesterone
• 17«alpha»-Acetoxy-6-methyl-4,6-pregnadiene-3,20-dione
• 17«alpha»-Acetoxy-6-methylpregna-4,6-diene-3,20-dione
• 17«alpha»-Acetoxy-6-dehydro-6-methylprogesterone
• 17«alpha»-Acetoxy-6-methyl-4,6-pregnadiene-3,20-dione
• 17«alpha»-Acetoxy-6-methylpregna-4,6-diene-3,20-dione
• 5071
• 6-Dehydro-6-methyl-17«alpha»-acetoxyprogesterone
• 6-Dehydro-6-methyl-17«alpha»-acetoxyprogesterone
• 6-Methyl-17-«alpha»-acetoxypregna-4,6-diene-3,20-dione
• 6-Methyl-17-«alpha»-acetoxypregna-4,6-diene-3,20-dione
• 6-Methyl-17«alpha»-hydroxy-«DELTA»6-progesterone acetate
• 6-Methyl-17«alpha»-hydroxy-«DELTA»6-progesterone acetate
• 6-Methyl-6-dehydro-17«alpha»-acetoxyprogesterone
• 6-Methyl-6-dehydro-17«alpha»-acetylprogesterone
• 6-Methyl-6-dehydro-17«alpha»-acetoxyprogesterone
• 6-Methyl-6-dehydro-17«alpha»-acetylprogesterone
• 6-Methyl-«DELTA»4,6-pregnadien-17-«alpha»-ol-3,20-dione acetate
• 6-Methyl-«DELTA»4,6-pregnadien-17-«alpha»-ol-3,20-dione acetate
• BDH 1298
• DMAP
• Magestin
• Maygace
• Megace
• Megeron
• Megestat
• Megestil
• Megestryl acetate
• NSC-71423
• Nia
• Niagestin
• Ovaban
• Ovarid
• Pregna-4,6-diene-3,20-dione, 17-(acetyloxy)-6-methyl-
• Pregna-4,6-diene-3,20-dione, 17-hydroxy-6-methyl-, acetate
• Progesterone, 6-dehydro-17«alpha»-hydroxy-6-methyl-, acetate
• Progesterone, 6-dehydro-17«alpha»-hydroxy-6-methyl-, acetate
• SC 10363

• C_p,gas : Ideal gas heat capacity (J/mol×K).
• Δ_fG° : Standard Gibbs free energy of formation (kJ/mol).
• Δ_fH°_gas : Enthalpy of formation at standard conditions (kJ/mol).
• Δ_fusH° : Enthalpy of fusion at standard conditions (kJ/mol).
• Δ_vapH° : Enthalpy of vaporization at standard conditions (kJ/mol).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• P_c : Critical Pressure (kPa).
• I_np : Non-polar retention indices.
• T_boil : Normal Boiling Point Temperature (K).
• T_c : Critical Temperature (K).
• T_fus : Normal melting (fusion) point (K).
• V_c : Critical Volume (m³/kmol).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Property	Value	Unit	Source
ΔfG°	-142.96	kJ/mol	Joback Calculated Property
ΔfH°gas	-675.71	kJ/mol	Joback Calculated Property
ΔfusH°	28.77	kJ/mol	Joback Calculated Property
ΔvapH°	87.52	kJ/mol	Joback Calculated Property
log10WS	[-5.35; -5.35]
log10WS	-5.35		Aq. Sol...
log10WS	-5.35		Estimat...
logPoct/wat	4.575		Crippen Calculated Property
McVol	307.560	ml/mol	McGowan Calculated Property
Pc	1454.57	kPa	Joback Calculated Property
Inp	[2909.00; 2909.00]
Inp	2909.00		NIST
Inp	2909.00		NIST
Tboil	994.47	K	Joback Calculated Property
Tc	1245.97	K	Joback Calculated Property
Tfus	694.49	K	Joback Calculated Property
Vc	1.169	m3/kmol	Joback Calculated Property

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
Cp,gas	[1143.19; 1395.81]	J/mol×K	[994.47; 1245.97]
Cp,gas	1143.19	J/mol×K	994.47	Joback Calculated Property
Cp,gas	1177.87	J/mol×K	1036.39	Joback Calculated Property
Cp,gas	1214.85	J/mol×K	1078.30	Joback Calculated Property
Cp,gas	1254.63	J/mol×K	1120.22	Joback Calculated Property
Cp,gas	1297.72	J/mol×K	1162.14	Joback Calculated Property
Cp,gas	1344.61	J/mol×K	1204.06	Joback Calculated Property
Cp,gas	1395.81	J/mol×K	1245.97	Joback Calculated Property

Similar Compounds

Find more compounds similar to Megestrol acetate.

Mixtures

• Carbon dioxide + Megestrol acetate
• Water + Megestrol acetate

Sources

• Crippen Method
• Solubility of megestrol acetate and levonorgestrel in supercriticalcarbon dioxide
• Solubility of Bicalutamide, Megestrol Acetate, Prednisolone, Beclomethasone Dipropionate, and Clarithromycin in Subcritical Water at Different Temperatures from 383.15 to 443.15 K
• Joback Method
• Aqueous Solubility Prediction Method
• Estimated Solubility Method
• McGowan Method
• NIST Webbook

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