Chemical Properties of Hydrocortisone (CAS 50-23-7)

InChI

InChI=1S/C21H30O5/c1-19-7-5-13(23)9-12(19)3-4-14-15-6-8-21(26,17(25)11-22)20(15,2)10-16(24)18(14)19/h9,14-16,18,22,24,26H,3-8,10-11H2,1-2H3/t14-,15-,16-,18+,19-,20-,21-/m1/s1

InChI Key

JYGXADMDTFJGBT-NDNUHCHRSA-N

Formula

C21H30O5

SMILES

CC12CCC(=O)C=C1CCC1C2C(O)CC2(C)C1CCC2(O)C(=O)CO

Molecular Weight¹

362.46

CAS

50-23-7

Other Names

• 11,17,21-Trihydroxypregn-4-ene-3,20-dione, (11«beta»)-
• 11,17,21-Trihydroxypregn-4-ene-3,20-dione, (11«beta»)-
• 11.beta.,17.alpha.,21-trihydroxypregn-4-ene-3,20-dione
• 11Beta,17,21-trihydroxy progesterone
• 11«beta»,17,21-Trihydroxypregn-4-ene-3,20-dione
• 11«beta»,17,21-trihydroxyprogesterone
• 11«beta»,17«alpha»,21-Trihydroxy-4-pregnene-3,20-dione
• 11«beta»,17«alpha»,21-Trihydroxypregn-4-ene-3,20-dione
• 11«beta»-Hydrocortisone
• 11«beta»-Hydroxycortisone
• 11«beta»,17,21-Trihydroxypregn-4-ene-3,20-dione
• 11«beta»,17,21-trihydroxyprogesterone
• 11«beta»,17«alpha»,21-Trihydroxy-4-pregnene-3,20-dione
• 11«beta»,17«alpha»,21-Trihydroxypregn-4-ene-3,20-dione
• 11«beta»-Hydrocortisone
• 11«beta»-Hydroxycortisone
• 17-Hydroxycorticosterone
• 17«alpha»-Hydroxycorticosterone
• 17«alpha»-Hydroxycorticosterone
• 4-Pregnen-11«beta»,17«alpha»,21-triol-3,20-dione
• 4-Pregnen-11«beta»,17«alpha»,21-triol-3,20-dione
• 4-Pregnene-11«beta»,17«alpha»,21-triol-3,20-dione
• 4-Pregnene-11«beta»,17«alpha»,21-triol-3,20-dione
• Acticort
• Aeroseb HC
• Ala-Scalp
• Alacort
• Anflam
• Barseb HC
• CaldeCort Spray
• Cetacort
• Cleiton
• Cobadex
• Compound F
• Compound F (kendall)
• Cort-Dome
• Cortanal
• Cortef
• Cortenema
• Corticreme
• Cortifan
• Cortiment
• Cortisol
• Cortisol alcohol
• Cortispray
• Cortolotion
• Cortonema
• Cortoxide
• Cortril
• Cremesone
• Delacort
• Dermacort
• Dermocortal
• Dermolate
• Dihydrocostisone
• Dioderm
• Domolene-HC
• Efcorbin
• Efcortelan
• Efcortelin
• Eldecort
• Eldercort
• Epicort
• Epiderm H
• Esiderm H
• Ficortril
• Fiocortril
• Genacort
• H-Cort
• HC
• Heb-Cort
• Hidro-Colisona
• Hycort
• Hycortol
• Hycortole
• Hydrasson
• Hydro-Adreson
• Hydro-colisona
• Hydrocorticosterone
• Hydrocortisone alcohol
• Hydrocortisone free alcohol
• Hydrocortistab
• Hydrocortisyl
• Hydrocortone
• Hydroxycortisone
• Hytone
• Hytone lotion
• Incortin-H
• Incortin-hydrogen
• Kendall's Compound F
• Komed HC
• Lacticare-HC
• Maintasone
• Medicort
• Mildison
• NSC 10483
• Nutracort
• Optef
• Otosone-F
• Penecort
• Permicort
• Polcort H
• Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11«beta»)-
• Pregn-4-ene-3,20-dione, 11,17,21-trihydroxy-, (11«beta»)-
• Pregn-4-ene-3,20-dione, 11«beta»,17,21-trihydroxy-
• Pregn-4-ene-3,20-dione, 11«beta»,17,21-trihydroxy-
• Proctocort
• Rectoid
• Reichstein's Substance M
• Scheroson F
• Signef
• Tarcortin
• Texacort lotion 25
• Topicort
• Traumaide
• U 1851
• Zenoxone
• anti-Inflammatory hormone

• Δ_cH°_solid : Standard solid enthalpy of combustion (kJ/mol).
• C_p,gas : Ideal gas heat capacity (J/mol×K).
• Δ_fG° : Standard Gibbs free energy of formation (kJ/mol).
• Δ_fH°_gas : Enthalpy of formation at standard conditions (kJ/mol).
• Δ_fusH° : Enthalpy of fusion at standard conditions (kJ/mol).
• Δ_fusH : Enthalpy of fusion at a given temperature (kJ/mol).
• Δ_vapH° : Enthalpy of vaporization at standard conditions (kJ/mol).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• P_c : Critical Pressure (kPa).
• T_boil : Normal Boiling Point Temperature (K).
• T_c : Critical Temperature (K).
• T_fus : Normal melting (fusion) point (K).
• V_c : Critical Volume (m³/kmol).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Property	Value	Unit	Source
ΔcH°solid	-11480.00 ± 30.00	kJ/mol	NIST
ΔfG°	-372.80	kJ/mol	Joback Calculated Property
ΔfH°gas	-892.33	kJ/mol	Joback Calculated Property
ΔfusH°	30.71	kJ/mol	Joback Calculated Property
ΔvapH°	120.46	kJ/mol	Joback Calculated Property
log10WS	[-3.09; -3.05]
log10WS	-3.09		Estimat...
log10WS	-3.05		Aq. Sol...
logPoct/wat	1.782		Crippen Calculated Property
McVol	279.760	ml/mol	McGowan Calculated Property
Pc	2147.32	kPa	Joback Calculated Property
Tboil	1117.27	K	Joback Calculated Property
Tc	1367.94	K	Joback Calculated Property
Tfus	[490.70; 494.75]	K
Tfus	490.70	K	Aq. Sol...
Tfus	494.75	K	Thermod...
Vc	1.046	m3/kmol	Joback Calculated Property

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
Cp,gas	[1185.49; 1514.13]	J/mol×K	[1117.27; 1367.94]
Cp,gas	1185.49	J/mol×K	1117.27	Joback Calculated Property
Cp,gas	1228.38	J/mol×K	1159.05	Joback Calculated Property
Cp,gas	1275.34	J/mol×K	1200.83	Joback Calculated Property
Cp,gas	1326.87	J/mol×K	1242.60	Joback Calculated Property
Cp,gas	1383.50	J/mol×K	1284.38	Joback Calculated Property
Cp,gas	1445.75	J/mol×K	1326.16	Joback Calculated Property
Cp,gas	1514.13	J/mol×K	1367.94	Joback Calculated Property
ΔfusH	[35.84; 35.84]	kJ/mol	[486.00; 486.00]
ΔfusH	35.84	kJ/mol	486.00	NIST
ΔfusH	35.84	kJ/mol	486.00	NIST

Similar Compounds

Find more compounds similar to Hydrocortisone.

Mixtures

• Ethanol + Hydrocortisone
• Acetone + Hydrocortisone
• 1-Propanol + Hydrocortisone
• 1-Butanol + Hydrocortisone
• 1-Propanol, 2-methyl- + Hydrocortisone
• Ethyl Acetate + Hydrocortisone
• Acetonitrile + Hydrocortisone
• Ethanol + Ethyl Acetate + Hydrocortisone
• Hydrocortisone + Water
• Ethanol + Hydrocortisone + Water

Sources

• Crippen Method
• Thermodynamic equilibrium of hydrocortisone form I in different solvent systems
• Solubility of Budesonide, Hydrocortisone, and Prednisolone in Ethanol + Water Mixtures at 298.2 K
• Joback Method
• Aqueous Solubility Prediction Method
• Estimated Solubility Method
• McGowan Method
• NIST Webbook

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