Chemical Properties of Glyburide (CAS 10238-21-8)

InChI

InChI=1S/C23H28ClN3O5S/c1-32-21-12-9-17(24)15-20(21)22(28)25-14-13-16-7-10-19(11-8-16)33(30,31)27-23(29)26-18-5-3-2-4-6-18/h7-12,15,18H,2-6,13-14H2,1H3,(H,25,28)(H2,26,27,29)

InChI Key

ZNNLBTZKUZBEKO-UHFFFAOYSA-N

Formula

C23H28ClN3O5S

SMILES

COc1ccc(Cl)cc1C(=O)NCCc1ccc(S(=O)(=O)NC(=O)NC2CCCCC2)cc1

Molecular Weight¹

494.00

CAS

10238-21-8

Other Names

• 1-((p-(2-(5-Chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl urea
• 1-(p-(2-(5-Chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexylurea
• 5-Chloro-N-(2-(4-((((cyclohexylamino)carbonyl)amino)sulfonyl)phenyl)ethyl)-2-methoxybenzamide
• 5-Chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxybenzamide (glyburide)
• 5-chloro-N-(4-(N-(cyclohexylcarbamoyl)sulfamoyl)phenethyl)-2-methoxybenzamide
• 5-chloro-N-[2-[4-(cyclohexylcarbamoylsulfamoyl)phenyl]ethyl]-2-methoxybenzamide
• Abbenclamide
• Adiab
• Apo-Glibenclamide
• Azuglucon
• Bastiverit
• Benclamin
• Benzamide, 5-chloro-N-[2-[4-[[[(cyclohexylamino)carbonyl]amino]sulfonyl]phenyl]ethyl]-2-methoxy-
• Betanase
• Daonil
• Diabeta
• Diabiphage
• Dibelet
• Duraglucon
• Euglucan
• Euglucon
• Euglucon 5
• Euglykon
• Gilemal
• Glibadone
• Glibenclamide
• Glibenil
• Glibens
• Glibil
• Glimel
• Glimide
• Glucolon
• Glybenzcyclamide
• Glynase
• HB 419
• HD 419
• Humedia
• Libanil
• Maninil
• Med-Glionil
• Melix
• Micronase
• N-(4-(2-(5-Chloro-2-methoxybenzamido)ethyl)phenylsulfonyl)-N'-cyclohexylurea
• N-(4-(«beta»-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
• N-(4-(«beta»-(2-Methoxy-5-chlorbenzamido)-aethyl)-benzolsulfonyl)-N'-cyclohexyl-harnstoff
• Orabetic
• Pira
• Prodiabet
• Renabetic
• Semi-Daonil
• Suraben
• Tiabet
• U 26452
• UR 606
• Urea, 1-((p-(2-(chloro-o-anisamido)ethyl)phenyl)sulfonyl)-3-cyclohexyl-
• Urea, 1-(p-(2-(5-chloro-2-methoxybenzamido)ethyl)benzenesulfonyl)-3-cyclohexyl-
• Yuglucon

• C_p,gas : Ideal gas heat capacity (J/mol×K).
• Δ_fG° : Standard Gibbs free energy of formation (kJ/mol).
• Δ_fH°_gas : Enthalpy of formation at standard conditions (kJ/mol).
• Δ_fusH° : Enthalpy of fusion at standard conditions (kJ/mol).
• Δ_fusH : Enthalpy of fusion at a given temperature (kJ/mol).
• Δ_vapH° : Enthalpy of vaporization at standard conditions (kJ/mol).
• log₁₀WS : Log10 of Water solubility in mol/l.
• logP_oct/wat : Octanol/Water partition coefficient.
• McVol : McGowan's characteristic volume (ml/mol).
• P_c : Critical Pressure (kPa).
• I_np : Non-polar retention indices.
• T_boil : Normal Boiling Point Temperature (K).
• T_c : Critical Temperature (K).
• T_fus : Normal melting (fusion) point (K).
• V_c : Critical Volume (m³/kmol).
• ¹: Molecular weight from the IUPAC atomic weights tables.

Physical Properties

Property	Value	Unit	Source
ΔfG°	-211.98	kJ/mol	Joback Calculated Property
ΔfH°gas	-691.14	kJ/mol	Joback Calculated Property
ΔfusH°	69.33	kJ/mol	Joback Calculated Property
ΔvapH°	131.99	kJ/mol	Joback Calculated Property
log10WS	-5.09		Aq. Sol...
logPoct/wat	3.642		Crippen Calculated Property
McVol	355.830	ml/mol	McGowan Calculated Property
Pc	1829.41	kPa	Joback Calculated Property
Inp	3531.00		NIST
Tboil	1179.37	K	Joback Calculated Property
Tc	1443.97	K	Joback Calculated Property
Tfus	[443.27; 446.98]	K
Tfus	443.27	K	Aq. Sol...
Tfus	446.98	K	Solubil...
Vc	1.351	m3/kmol	Joback Calculated Property

Temperature Dependent Properties

Property	Value	Unit	Temperature (K)	Source
Cp,gas	[1162.69; 1175.70]	J/mol×K	[1179.37; 1443.97]
T(K) Ideal gas heat capacity (J/mol×K) 1162 1164 1166 1168 1170 1172 1174 1176 1200 1300 1400
Cp,gas	1169.90	J/mol×K	1179.37	Joback Calculated Property
Cp,gas	1173.89	J/mol×K	1223.47	Joback Calculated Property
Cp,gas	1175.70	J/mol×K	1267.57	Joback Calculated Property
Cp,gas	1175.41	J/mol×K	1311.67	Joback Calculated Property
Cp,gas	1173.09	J/mol×K	1355.77	Joback Calculated Property
Cp,gas	1168.82	J/mol×K	1399.87	Joback Calculated Property
Cp,gas	1162.69	J/mol×K	1443.97	Joback Calculated Property
ΔfusH	[46.30; 53.35]	kJ/mol	[446.80; 450.20]
ΔfusH	46.30	kJ/mol	446.80	NIST
ΔfusH	53.35	kJ/mol	450.20	NIST

Similar Compounds

Find more compounds similar to Glyburide.

Mixtures

• Glyburide + Methyl Alcohol
• Glyburide + Ethanol
• Glyburide + 1-Propanol
• Glyburide + Isopropyl Alcohol
• Glyburide + 1-Butanol
• Glyburide + Acetone
• Glyburide + Acetonitrile
• Methyl Isobutyl Ketone + Glyburide
• Glyburide + Acetic acid, methyl ester
• Glyburide + Ethyl Acetate
• Glyburide + Acetonitrile + Acetone

Sources

• Crippen Method
• Solubility Determination and Correlation of Glibenclamide in 11 Monosolvents and (Acetone + Acetonitrile) Binary Solvents from 283.15 K to 323.15 K
• Joback Method
• Aqueous Solubility Prediction Method
• McGowan Method
• NIST Webbook

Note: Cheméo is only indexing the data, follow the source links to retrieve the latest data. The source is also providing more information like the publication year, authors and more. Take the time to validate and double check the source of the data.